Yes. A final rejection from the United States Patent and Trademark Office can be appealed to the Board of Patent Appeals and Interferences. An appeal requires an appeal fee and the applicant must file appeal brief in support of the applicant’s position. For an additional fee, an appeal can include an oral hearing. The decision of the Board of Patent Appeals and Interferences may be appealed to the Court of Appeals for the Federal Circuit (CAFC) or a civil action may be filed against the Director of the United States Patent and Trademark Office in the United States District Court for the District of Columbia.